Advair: weight gain & appetite?

[Possegal]

The label for Advair has nothing about weight gain and I just did a cursory look at the medical review for it when it was approved and I didn't see anything in there. I would think the systemic levels of the steroid should be lower with the inhalation than with oral, again, just my thinking. There is a reason the Advair label does say to use caution when switching from an oral steroid to Advair. This is because when you are taking the oral steroid, your adrenal gland notes the steroid in your blood and shuts down making more, so then the corticosteroid in your system is from the pill and not from your natural system of making it. You taper off a pill like that to allow your adrenal gland to note less corticosteroid in the system and ramp up production again. If the Advair supplied as much corticosteroid to the blood, then you wouldn't have to worry when switching from oral steroids to Advair. And for you to have increased appetite, the steroid has to be in the blood to get to your brain to stimulate your eating. That's my take on it. I was looking for some comparative pharmacokinetics, but couldn't find any or at least not in the timeframe I had in my schedule.

and the throat changes and hoarseness are in the label as some of the most common side effects of the drug.

Always ask your pharmacist, usually they know the most about these things.