Advair: weight gain & appetite?

[Miranda]

I used Advair for about 6 years. I don't think it caused any weight gain. I've been taking Depakote for migraines for over 15 years and that definitely affects my weight/appetite, but I didn't notice any difference when I started with the Advair.

This is going back a few years so I don't remember all the details, but I suspected that the Advair caused some minor and very short-lived throat irritation (my voice sounded slightly different) when I started to use it and later increased the dosage. Also I had a series of colds at one point that I thought might have been related to increasing the dosage. But that was also a short-term thing and since then I've definitely gotten fewer upper respiratory infections than I used to get.

Last year my doctor switched me to Pulmicort which contains only one medication and is a corticosteroid. (Advair is two meds.) I've been pretty much the same since making the switch, i.e., no changes either in asthma symptoms or side effects.

My father has been using various asthma meds for 15+ years, including Advair for at least 5 years, and he hasn't mentioned any negative side affects from it.

In general you shouldn't stop taking medications without talking to your doctor first. Also try asking your pharmacist if weight gain is a side affect of Advair -- pharmacists are a great resource for information on meds.

Good luck.

Thx for your help. I know exactly what you are saying about the throat/voice changes. It's like you have a gurly frog in your throat. Like a soar throat sound, but not the normal full soar throat feeling of pain. It's good to know that it did subside with time. Also, about the weight loss. Maybe it's another one of the meds. Think I'll have to pull a full review. The doc was on vacation last time I checked in. His NP and I talked a bit about it. She said it's hard to figure out which med is doing what when there are diff ones. The pharm is a good tip. We have one really good guy at ours. Think I'll have to seek him out. Thinking the doc will be back soon from travel.

[Possegal]

The label for Advair has nothing about weight gain and I just did a cursory look at the medical review for it when it was approved and I didn't see anything in there. I would think the systemic levels of the steroid should be lower with the inhalation than with oral, again, just my thinking. There is a reason the Advair label does say to use caution when switching from an oral steroid to Advair. This is because when you are taking the oral steroid, your adrenal gland notes the steroid in your blood and shuts down making more, so then the corticosteroid in your system is from the pill and not from your natural system of making it. You taper off a pill like that to allow your adrenal gland to note less corticosteroid in the system and ramp up production again. If the Advair supplied as much corticosteroid to the blood, then you wouldn't have to worry when switching from oral steroids to Advair. And for you to have increased appetite, the steroid has to be in the blood to get to your brain to stimulate your eating. That's my take on it. I was looking for some comparative pharmacokinetics, but couldn't find any or at least not in the timeframe I had in my schedule.

and the throat changes and hoarseness are in the label as some of the most common side effects of the drug.

Always ask your pharmacist, usually they know the most about these things.

[hirakukibou]

Like nybiker, I took Advair and had throat irritation to the point where my doc changed my med to Qvar which is similar to Pulmocort. It is a steroid inhaler without the extra albuterol. I didn't have weight gain from the Advair or Qvar from what I can tell.

Good luck with figuring out the meds. I know that can be quite a process. I am *still* working to fully control my asthma.

[Possegal]

For clarification purposes - Advair does not have albuterol in it. Albuterol is a fast acting beta agonist which quickly dilates the bronchioles. Advair contains salmeterol, a long-acting beta agonist that works over time, not rapidly. This is why the label for Advair tries to alert people to the fact that it is not a 'rescue inhaler', as we often call albuterol. It should not be used in the event of an attack.

The recommendation for Advair also states that if you can be controlled on an inhaler that is just the steroid component, then you should do that. Glad to hear that switching has helped you. I think at my next dr. appt I'm going to look to switching myself, as I think something like Pulmicort would work fine for me and be better for me.

[Miranda]

The label for Advair has nothing about weight gain and I just did a cursory look at the medical review for it when it was approved and I didn't see anything in there. I would think the systemic levels of the steroid should be lower with the inhalation than with oral, again, just my thinking. There is a reason the Advair label does say to use caution when switching from an oral steroid to Advair. This is because when you are taking the oral steroid, your adrenal gland notes the steroid in your blood and shuts down making more, so then the corticosteroid in your system is from the pill and not from your natural system of making it. You taper off a pill like that to allow your adrenal gland to note less corticosteroid in the system and ramp up production again. If the Advair supplied as much corticosteroid to the blood, then you wouldn't have to worry when switching from oral steroids to Advair. And for you to have increased appetite, the steroid has to be in the blood to get to your brain to stimulate your eating. That's my take on it. I was looking for some comparative pharmacokinetics, but couldn't find any or at least not in the timeframe I had in my schedule.

and the throat changes and hoarseness are in the label as some of the most common side effects of the drug.

Always ask your pharmacist, usually they know the most about these things.

For clarification purposes - Advair does not have albuterol in it. Albuterol is a fast acting beta agonist which quickly dilates the bronchioles. Advair contains salmeterol, a long-acting beta agonist that works over time, not rapidly. This is why the label for Advair tries to alert people to the fact that it is not a 'rescue inhaler', as we often call albuterol. It should not be used in the event of an attack.

The recommendation for Advair also states that if you can be controlled on an inhaler that is just the steroid component, then you should do that. Glad to hear that switching has helped you. I think at my next dr. appt I'm going to look to switching myself, as I think something like Pulmicort would work fine for me and be better for me.

Thx for that info! I wondered what the diff was between the short acting beta agonist, and long acting. I knew that the albuteral was the quick acting drug for rescue, but didn't realize the Advair has this component long term. DD takes Pulmacort via the nebulizer. The doc tried to give me the newest stuff out, Simbacort. Pulmacort PLUS a short acting dialator--made me feel really wigged out. My albuterol does that to me short term, then passes.

[Miranda]

Like nybiker, I took Advair and had throat irritation to the point where my doc changed my med to Qvar which is similar to Pulmocort. It is a steroid inhaler without the extra albuterol. I didn't have weight gain from the Advair or Qvar from what I can tell.

Good luck with figuring out the meds. I know that can be quite a process. I am *still* working to fully control my asthma.

Thx for your reply. It is a puzzle to figure out the meds. It's frustrating sometimes having athletic passions, and your body doesn't want to join in the passion correctly (like breath right).

My docs have told me before that this is actual in our favor as asthmatics. I guess the more sedentary you are, the less physical exertion it takes to trigger the asthma.

I hate it when they do that stupid lung capacity test in the office. The mini-machine (like a peak flow meter, but it's electronic, and produces a graph) breathing test. The RN showed me last time: "well... for your age etc., your average normal range of lung capacity is X... and you are ok, or above that".

OK, that's a good thing. But I don't think it compares apples to apples when you consider endurance athletes and what our lung capacity is (or needs to be for the sports performance)... compared to a coach potatoe.