My bike came with a saddle that was too narrow for my sit bones, so I wound up putting more pressure in the wrong area. This led to bruising and soreness on the pubis, but not chafing or pinching in the crease of the leg or on the sitbones.

I then switched to a wider saddle. Things were better, but then I started getting chafing in the hot months.

I finally switched to a harder, thinner racing saddle (still with a cutout), and a lot of the chafing and pinching went away, because I now have the maximum stability under my stibones. Now the only problems I have are definitely correlated to the shorts--seams, looseness in the chamois area over time, or the fabric covering the chamois. I can only do so much about that, because I go with what the team gets. I just try to get the snuggest fit that I can and lube up.

FWIW, I ride with the saddle pretty nose-down for a girl. My crit racing position is even lower than where I may put it for long rides in the fall, to make it even more nose-down and comfortable when I'm in the drops. I don't think I'll have to move this saddle any, though, because it's gotten very broken in and molded to me, unlike the others.