More than likely, yes. Most road shoes have a 3 screw mount for cleats, the Frogs take 2 so the cleat area on the road shoes may not be large enough to accommodate the Frog cleats. Would you consider a platform pedal for the knee? I have a bad knee too and I have found the platform agrees with me when I have to stop and start alot. On my road bike I use the Frogs since I don't have to clip in and out often.




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