I have a friend going through the same thing right now, he's tired of being at the whim of his professor's research/job changes/etc.. He started his job search for a tenure track faculty position with his own lab (what he's been working towards his whole academic career) and has found the process so disheartening that he's moving away from academia into a private sector job. He works on brain chemistry stuff and the private sector will offer him a job that interests him ( AND pays him well) without him having to write all the grants to pay his salary.