The label for Desyrel(R) - trazodone hydrochloride, does say that it selectively inhibits serotonin. I see it referred to as a selective inhibitor in a few places. A very quick search of some journal articles shows me that it acts differently than the average SSRI but I don't think this is a non-selective one. It is often referred to as an atypical antidepressant. The typical serontin inhibitor (like prozax or zoloft) act to block the uptake of serontonin back into the cell after it has been released. Trazodone appears to act by blocking a serotonin receptor rather than inhibition of its uptake. And yes, 'less picky' would be one way of putting it if one is called non-selective. Non-selective serontonin uptake inhibitors will also act to inhibit other neurotransmitters such as norepinephrine and/or dopamine. Also keep in mind that all drugs have a myriad of actions. In my opinion, no drug is truly selective, but it is a matter of degrees.

Don't know if that helped any, but thought I would try and answer the 'selective' versus 'non-selective' issue.

And as others have said, everyone's reactions to drugs are very different and so it is worth trying a few different ones. If you aren't happy with one drug, another may work just fine for you. I know several people who swear by Paxil and also several who found it very difficult to take.