The tips on cleaning and chamois varieties and chamois butter (or simply vaseline!!) work. Add me to the list of the seat not making the difference. For me, same seat is good or truly evil depending on position. If I am not on my fitted bike (yes, I am spoiled) and take my seat and pedals for a rental on a trip, it can be the greatest bike in the world but if the seat position is off, PRESTO the sores reappear. Get a proper fitting and it may we start clearning up!