For years I got blisters on my arches from any orthotics I tried. I used all kinds of tapes and bandages with varying degrees of protection, but I could never guarantee I wasn't going to come home with a 2" x 1" blister on my arch. I don't know why I never believed lubes would work on my feet, but this fall I discovered Blister Block and I haven't had a problem since.
I don't know how well it would hold up over long runs, but after 6 miles it doesn't feel like it's starting to wear off at all.