I had the problem you mention, and found a few things are key:

1) Level the nose, not whole saddle, (and I also need it all the way back onr rails).

2) good chamois.

3) be sure its not set too high. set height from height of rear where your sit bones sit, and try slighly lowering to see if pressure resolves (since there isn't any gel to sink into sometimes you may need to slightly decrease the overall saddle height.