If you get a good compact (such as DA) and FD, you should have no problems shifting between the 34 and 50. I find my FSA is finicky a lot of the time, and there's nothing I can do with my 105 FD to make it better. AND I have a 36 small ring. I just have to be mindful of where on the cassette I am when I shift.
With the MTB cassette, have you thought about a 36 small ring? You might be able to spend more time in the small ring that way and less time shifting back and forth. Plus, shifting with the 105s might be a tad easier. 36 rings are a little harder to find, though.
Also keep in mind if you want to use the same crankarms what your BCD is. Compacts are generally 110mm while 130mm is common for other cranksets.



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