It could be as dire as the frame, or not much, as Eden indicated. I don't know much about all this stuff, except that I also experienced a nasty creak under heavy load with rotation of cranks last summer. I took the bike in for a basic overhaul, rather than just the little yearly tune-up, and they didn't really discover the problem, but the overhaul took the creak away, too. No problem since.
"The best rides are the ones where you bite off much more than you can chew, and live through it." ~ Doug Bradbury