Everyone is different, but I will tell you my experience with sinus infections. I have chronic sinus infections, have had them for years. I used to get active infections that would last for eight-ten months at a time, and the whole time I would be going through all the medical hoops, with little relief, and I would just kind of shut down and not do anything until it all finally went away.
After a couple of years of that (this all started when I was about 25 and has been pretty constant ever since, and I am 35) I kind of snapped and realized exactly how much of my life was I was literally wasting being stuck in the house with a headache. I wasn't just bellyaching; the headaches are pretty debilitating. The thing is, rest has never helped me. Not once. Lying on the sofa with a cold compress has never given more than a tiny bit of relief. I might as well have a headache while I'm doing something that I enjoy, which might even take my mind off the problem.
Lo and behold, exercise does help. Between extreme hydration when I have an active infection (drink a big glass of water every hour), OTC stuff like Claritin and the grossly-named Mucinex, and regular aerobic exercise, I'm much better off than I used to be. I still get the infections but I can mostly shake them off or live with them. (My doctor doesn't want to give me antibiotics anymore because I've taken so many of them to no effect over the last ten years.)
The times I do rest: when I have a significant fever, when I am just plain exhausted, and when I am having dizzy spells. If you're dizzy from all the inner ear stuff it's best not to do anything that's going to hurt if you fall down.



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