Some good advice here already. Congrats on your great ride! YAY!

1) I used to get sore between my thumb and index finger, and for the first couple of years I took to lubing the area with neosporin before putting on my gloves. Made all the difference, and now I never need it anymore. I guess I just out-grew the problem, or got a callus, or whatever.

2) You can get shims to make your 105 brakes easier to reach. In fact, mine are double-shimmed. That is not ideal for me, and when I get a new bike, I will get short reach shifters and a woman's bar. But, for now, for this bike, for my budget, it works OK.