Having done two seasons of marathon training (nope -- haven't run in a marathon yet -- two long stories...), I've had my share of blisters, including blisters on the balls of my feet. Once they've gotten to the point yours is at, they'll heal fastest if you drain them. Use a needle sterilized in lots of alcohol, and bathe the blister liberally in alcohol after draining it (you may need to use the needle in more than one place), and don't peel away the skin. If you're going to be at home/barefoot or wearing sandals, use antibiotic ointment and a bandaid. If you're going for or a run or ride and wearing socks, there's no way a bandaid will stay there, so just try to keep the blister clean, and clean/cover it afterwards.
It's definitely possible to run or otherwise be active with a blister on the bottom of your foot if you drain it as necessary.
Moleskin isn't really useful before a blister has popped -- you cut it in a donut shape to go around the blister, and what it does is create a raised area around the blister so fabric/shoes/bandaids etc theoretically don't touch the blister -- a new blister will be higher than the moleskin, so it doesn't do anything. Generally I find moleskin to be more trouble than it's worth -- the friction/pounding of running and possibly riding still means that fabric/bandaid/etc will be pushed past the moleskin into the blister, especially if it's on the bottom of your foot. But every person is an experiment of one, so...



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, I'm outnumbered by people who know more than I do!!!
