Hi - I have the Cannondale Singletrack shorts and HATE them - the elastic just seems way tighter on my admittedly chubby thighs than other shorts I now have. Larger size didn't help, because the smaller pair were already a little large in other areas. I bought some Shebeest shorts and it solved the welps problem.

Have you tried flipping the elastic up so that at least its not rubbing/gripping on your leg. I couldn't do that because these were kinda short and having the tight elastic up higher on the leg was terrible.

Hope that helps - I just found that Cannondale shorts and my thighs don't mix well...