For me it depends on the road. If its further out of town, two lane country road type of thing, I'm fine with the runners going against traffic. You can see them from far away and generally have plenty of time to look back and check for traffic to make sure it's safe to pull out around them. However if its closer to, or in town where there is a designated bike lane, it really irritates me when I see anything other than a bike in the bike lane. (Or a bike coming in the wrong direction, but that was another thread). It is a BIKE lane. See, right there, the little picture of the guy on a bike, right there on the road? There is not a picture of a runner, please do not run in the bike lane! Or if you must, please move out of the way since it is much easier for you to move, being that you're travelling slowly on two feet which allow you to move laterally very easily.

Smilingcat- I look at that situation as "bikes are vehicles". If the runners saw a car coming, would they move out in the middle and expect the car to pass on the right of the road? NO! Duh! That scene would have had me shouting some serious expletives.