I swear by this stuff..I use pacelines chamois creme, can be purchased from TE or other bike catalogs. I don't like "generic" chamois creme, the one I tried was more liquid than creme. It prevents horrible irritation for me, I apply to my parts that get irritated and to the seam areas of the chamois, and sometimes to the chamois itself depending on how much I squirt out and need to dispose of. Never had problems with UTI's as of yet.