I second the checking your wrist angle. I had new handlebars installed this year (narrower bars to match my shoulders). After I got the bike back, I was having problems with the wrists and numbness in the hands. When they put the new bars on, they attached the brakes at such an angle that my wrists dipped down. I tried it, but after about 7 miles, my wrists and hands starting having problems.

I tried just flattening out the bars. That helped, but the hoods were still too angled for me. So I had the shop move the brakes. Now, when I look at my hands when I grip the handlebar my wrists are straight. No more pain.

Give it a look. When you're riding your bike, do you have an odd angle to your wrists? If so, have them change it so you don't.