I'm a newbie to riding, so I make my BF stop every 10 miles or so (I think I've only really done "easy" rides. I'm terrible at hills/inclines). I don't have the bathroom issue, but I do need to stop for a drink (I haven't quite mastered the skill of grabbing the water bottle while riding) and a Gu. I think the most I've gone without stopping is 13 or 14 miles.