I have Keo Sprints--a platform pedal system--on my bike and like them quite a bit. I went from SPDs to those and, admittedly, they took a little getting used to. It helped tremendously to loosen the tension on the pedals so that it was easier to clip in and out. The first weekend I had them, I remember being pretty frustrated. The action needed to push down on the pedal and clip in just didn't seem intuitive. The guys at the LBS took a somewhat frazzled call from me that first weekend and assured me that it would get easier. True to their word, it now seems like second nature to me, and it never occurs to me that they're "one sided." Every once in a while, I find myself looking down to clip in but as a general rule I can easily do it by feel. I would also note say that they became easier to use after I had a professional fitting done on my bike. My saddle was moved back quite a bit and that put my leg and foot behind the pedal a bit more.
Just a few other notes. Walking in the cleats is possible, but you have to be careful on smooth surfaces like tile. They make cleat covers for them though. If I know I'm going to be walking a lot on a given day, I bring them along. The cleats eventually wear out and have to be replaced. They're not terribly expensive, but I haven't found it terribly easy to get them exactly where I want them. My fitter placed my cleats as part of my fitting so I just go back to him now when I need new cleats. With Keos, there are three different cleats from which to choose. One provides some float, one that provides a lot of float and one that provides zero float. I suppose you could mix and match if your knees required it.
Live with intention. Walk to the edge. Listen hard. Practice wellness. Play with abandon. Laugh. Choose with no regret. Continue to learn. Appreciate your friends. Do what you love. Live as if this is all there is.
--Mary Anne Radmacher