I'm a lefty, too, and just can't cope with the idea of putting a messenger bag on the "wrong" shoulder. (though the USAT Timbuk2 bag had me seriously tempted)
Thinkin' a backpack is in my future just for the bus commute I'm doing. Maybe one of those Ortlieb systems that let you turn a pannier into a backpack.
Keep us posted on how riding with a "righty" messenger bag goes, ok?



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) reflective panel. It's so over-the-top obnoxious that I always take it out when I'm riding at night, even if I don't need to carry anything. It's amazingly waterproof. Those are benefits, but of course you can get that in a good backpack. But I do like that the messenger bag is more cyclist-friendly in terms of visibility and keeping stuff dry on a commute.
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