Some parts toughen up and some parts don't; your "sit bone" area will but not the other parts (I don't even want to think about calluses there). No, you need a different saddle. Go check with your LBS about which saddles have return policies so you can try them. I personally love the new anatomic cut Avocet Air 02. There is an indentation in just the right place for these parts that I haven't seen in other brands. Avocet used to have a return policy. I've never tried a cut-out saddle so I can't compare, but I have heard that you either love them or hate them -- no middle ground.