I'm not sure what the right thing is, but I've definitely noticed different pressure points on the tri-bike saddle (and I've used the same saddle on road bikes so it's not the saddle).

Generally, if I have trouble on a road bike, it's at the sit bones. On the tri-bike I've noticed I'm really sitting on the bones to the side of the front parts. I'm using a Terry Liberator (not exactly designed for triathlons) which is a little wider in the front. I think the width takes the pressure off the soft parts and puts it on the bones. I'm not sure where the pressure is supposed to be, but this seems to work okay for me (I made it through a HIM last summer without any significant distress).

I'd be careful about tilting the saddle too far down (it can cause you to slip forward- causing you to constantly have to push back, and fatiguing your neck and upper back over time). Have you tried more than one saddle?