I have the liberator saddle on my bike, and I find if I don't use chamois cream on the longer rides i become "irritated" where the crease is of my thigh buttock area. I also shave and have to avoid shaving before going on longer rides which has also helped. But i swear by the chamois butt'r offered here. Also makes a difference on what type of chamois is in the shorts for me also. I've ditched the soft non formed piece of material to chamois that are different in thicknesses. All of the combinations for me has helped. But the butt'r is heaven. I've used it for a year now faithfully, no UTI's for me. But I apply to the outer labia and buttock area only.