I started having terrible pain problems when I got my new bike. Two saddles later (I switched back to the first new one recently), I think it was a combination of things. I started using the butt'r and it does help immensly on long rides. I use it everywhere and have had no issues with infections. But, I still was having severe pain in the girly area, so when i went for my annual exam, I told my doc. It seems like the post menopausal problem of thin, dry membranes was really affecting my cycling and when I got my new bike, somehow the slightly different geometry made my seat which i had loved for years aggravate this. I started using an estring, which is like those birth control loops, that supplies a teeny amount of localized estrogen to the vaginal area. My doctor told me that oncologists allow their post mastectomy patients to use it, so it is not like taking oral estrogen. After about 3 months, the issue is completely vanished. Hopefully, i won't have to use it forever, but it was actually getting to the point of making me want to stop riding. I still use Butt'r on longer rides (more than 30 miles) and it just makes the ride feel better.