I've had trouble with cramps in my left calf. I had a doppler run to rule out thrombophlebitis. What I figured out studying the meds I am on is that the birth control pills I took to fix my periods were clashing with the Advair, that caused the periods to get screwy in the first place. Advair can also cause thrombophlebitis, leg cramps, and edema.

You might want to check any meds you are taking and see if that may be the problem. My leg is still sore but I am hoping that things will clear up soon.

And here is something I learned from SCUBA diving: as soon as you feel that leg cramp pull your toes up. Pointing toes will make it worse. Dorsiflexion stretches out the muscle and stops the cramping.