I haven't had a wreck, but this is how I chose to run. The logic from DH is that you can see the cars coming at you and move off the road if there is some irratic driver. Usually this is an area with very little car traffic and even less bike traffic. Mainly boring little neighborhood roads.

When I am running on the hike and bike trail I use the same precautions as Limewave. It is easier to run on the grass than it is for a cyclist to swerve on that packed trail material.