Everyone is a bit different in their shape and how they are put together.
I had read abou thow women's saddles do well when tilted a bit down at the nose. I set my Brooks up that way- just a BIT tilted down from horizontal.
It was awful for me! I kept having the feeling I was sliding forward and it made me put too much WEIGHT on my hands! I was literally using my hands to keep me from sliding forward- and this was the result of just a TINY bit of downward nose tilt! I readjusted my seat to be perfectly horizontal and the problem was instantly gone and I was comfortable!
Many folks say the more foam and pads and gel on your saddle, the more they become bumps that are pushing back against your tissues when you mash down on them. Again, everyone is different. I am comfortable on my plain leather Brooks with no padding or cutouts or gel pockets.