Absolutely. I have lupus which is a chronic disease where your immune system attacks your own tissues. So, fatigue & arthritis are constant as well as mouth/nose sores & other irritants.
I take a medication every day that helps my energy level. I have to be careful in the sun. Sometimes I take Vioxx for the arthritis. And sometimes I have to slow down. I've had to make that be OK - which is hard for a competitive, type A personality who doesn't want to rely on anything - especially medication.
Listen to your body. Do a little something every day - even if it's just a walk.