I'm not a medical type but I do have bad allergies......I usually let my body tell me how I feel about the bike. I commuted all winter with on/off sinus infections, as long as it wasn't in my chest and I wasn't coughing. I just kept in mind that my rides would be slower and I would need to be sure I got plenty of rest. My daily commute is only 12 miles tho, I never did any long rides during that time (too cold lol).