I have some different ideas about comfort on the bike, so I just thought I'd throw them out there for consideration.

First of all, perhaps I'm overly paranoid, but I really hate the idea of smearing petroleum-based products on my erm...girly bits. In the past if I have had "frontal" irritation I would use a bit of good-ol' KY jelly on the sensitive parts. It's water-based so it's probably not the solution for those complaining that their chamois-lube wears off. It just helps make that first hour or so in the saddle more comfortable.

The second thing to consider is that Chamois Butt'r and Assos cream are made to be applied to uhm the exterior surfaces. They are great if you are experiencing chafing in the sit-bones region or inner thighs. Be especially warned that Assos cream contains menthol (or it did last time I tried it) and should NOT be applied to previously-mentioned "girly-bits" (uhm unless you are really into that kinda thing ).

The third thing to consider (actually "things") is "what exactly is causing the irritation?" I dunno about you ladies, but if I am geting rubbed the wrong way, I want to know "why" or "what".

If you have been putting in serious miles for 3+ months are are still getting soreness and/or chafing it's time to consider 1. a different saddle, 2. different bike shorts, 3. riding style and/or, 4. bike fit.

Personal story: I rode ~160 miles ( ~7 hours on the bike) with no "lube" and no major irritation this past weekend. Not bragging; just trying to give some of you some hope! I'd rather not mention brand-names; what works for me may or may not work for others. Just hoping to make the point that experimenting with gear and positioning is sooooo worth the effort.