Although, I never owned men's shorts or wore them I would assume that the difference is that men's have more padding in the front and a little bit differnet fit on your waist. I say if it fits you then go for it. Definately let us know what you thought about it. I am currently wearing Sugoi Lucky shorts, not to impressed with them but they are not bad at all. Also have SSS shebeest shorts, I like them but I find chamois a little to foamy (def not for long distance).