I race mountain bikes and run stans sealant with a tubless set up. It allows me to not carry tubes or a bike seat bag. I can run my tire pressure lower because I won't get pinch flats (and I'm a lighter rider so I don't have to worry about burping air out the sidewalls like heavier rides do). I do carry CO2 with me. If I do get a flat all I would need to do is add the C02, then spin the wheel so the stans can fill in the gap. In a race, I can flat and have it fixed in 30 seconds with this set up.
I haven't used stans with a tubed set up and I'm not sure that I would use it with tubes (but some people do). I would guess that it would be a little messier when you are running tubes. The sealant does dry out and you will need to clean out your tire and reapply every so often.
On a tubeless set up you may need to use compressed air to seat the tire (I have to with my Kenda Karma tires and Bontrager wheels). I have to bring the psi up to 60, the tire pops like a fire cracker and then it is properly seated. I would guess you wouldn't have to worry about this on a tubed tire set up.
Many of the Expert and Sport racers that I race with use stans and believe in it (though most use a tubeless set up or have converted their tube tires to tubless).
www.notubes.com



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