Yes. There are a couple versions of customization. You can get a nice frame, that comes in standard sizes, and building your bike from scratch. Or, you can go full custom, have the frame geometry design for your body and then build the frame up from scratch.

If you have some time on the bike though, you have an idea of what you like/dislike and you really want a full custom, go for it! I would recommend finding a really good lbs that has a nice fit system and is willing to spend a good amount of time with you finding the perfect frame geometry. Once you find that right fit, they're oh so comfy! I have a custom mtb frame and I LOVE LOVE LOVE it!!!