Thanks for the replies!

NWG, I will definitely look into what could be done to lower the gears on my Trek. I have a triple crank, not a compact, btw. It seems like the last time I researched it, it would require changing the rear derailleur for a long-cage and some other mods as well. But it certainly might be doable, and I'd like to see what it would cost vs. a new bike. Since it's a 10-year old bike, even though it fits me, I'll have to decide how much more to put into it vs. buying new. I do like steel (and that is what my Bike Friday is made out of), but I don't want a touring bike or a cross bike or a utilitarian bike (I consider my Bike Friday to be all of those things and will always keep it for those reasons), I want a performance road bike (with a more comfort geometry, tho) that is as lightweight as I can afford. I am petite and weigh < 105 lbs myself, so the lower I can get my bike as a % of my body weight the easier I can climb and attempt to stay with my DH, who still climbs like a mountain goat at 62, darn it!

Sheila, I looked at the Pinarellos briefly, but the gearing isn't low enough. One really nice women's model I was looking at was a 36/50 (or 52) compact in front and only a 25-tooth large cog in back...eeek. I know that can be switched, but often at an additional cost, especially since I'd want both front and rear to offer lower gears. I found their website fairly hard to navigate, though, so I might have missed a bike with lower gearing.

Crankin, I agree that the Di2 is not necessary, and it will probably be out of my price range too, but it does sound pretty sweet!