I have recently discovered that some of the tenderness of my sitting parts has to do with yeast, not bacteria, so some of the chamois creams actually aggravate the problem rather than helping it. Managing the sitting parts while not on the bike has made the biggest difference for me getting the problem under control. Going commando a lot and actively trying to keep the area dry while not riding has helped the most. (I realize this isn't practical for everyone, but it definitely helps me) Applying Gynelotrimin to the welts and bumps that form has also helped. I think our recent stretch of abnormally hot weather helped make the problem worse. I actually had to quit the STP around 150 miles because of a saddle sore so bad that it required antibiotics and nearly a month off the bike. After the wound healed I was able to ride RSVP with no ill effects--but I really had to be vigilant about keeping the sitting bits clean and dry.