I've worked at the same office since December 2000. Since February 2002 I've lived 4 miles from my office. From spring through early/mid autumn, I bring my bike to work once a week and go for a nice hilly ride after work.

Today I found out we are moving to a new facility in an industrial area of Washington DC. One of my first thoughts was, how will I do my weekly bike ride????

This is actually a pretty major life change, since in addition to the longer commute I will probably lose my ability to work flexible hours, and I won't be able to do things like run errands at lunchtime or on my way to/from work. So, less free time and more things to get done in my free time. And getting up earlier, so having to go to bed earlier, which again means less free time.

Not the biggest problem in the world, but not good.