Honestly, there are a lot of things at play here: brain chemistry, various types of hormones, perimenopause, upbringing, family history, personality, etc. Any number of things could cause the cluster of symptoms that the OP is experiencing, and our own experiences with this or that are only so instructive. I think the best thing at this point is for Brandi to go her doctor or doctors with an open mind. Listen carefully, take notes, ask questions, do some independent research depending on what any tests or assessments reveal, ask some more questions. Hopefully, there will be some clear answer as to what's wrong and an effective treatment.