I'm curious as to why women are more predisposed to experiencing renal complications due to prolonged NSAID use? I have been researching this topic and I find that in many cases is says women over 30 are much more at risk of developing this but no good and detailed description as to why??? I know several of you work in medicine so I thought I'd give it a shot on TE to see if anyone wants to share some info. I've determined a general cause that applies to men and women but I'm still not clear as to why women are MORE at risk. Basically it sounds that the NSAIDS impair the kidneys ability to concentrate urine properly. The only possible linking factor I ran across that makes sense is dehydration. Maybe due to monthly cycles women have more fluid loss? The typical patient that experiences analgesic nephropathy is considered to anemic, experience many headaches, female over 30 and had history of stomach ulcer. These are the signs the docs are supposed to look for. Any insight appreciated.