The same thing happened to me, the pain in the ball of the foot, but for me it was after mile 40, endurable only up to about mile 70. I kept the SPD pedals for too long, tinkering with the stiff sole shoe and moving the cleats further south on the shoe, then finally gave it up and moved to the Look Keo Max. And I am in love with my new pedals. Zero pain. No hot spots. And I have increased speed and power. I wear a Specialized road shoe with the carbon sole and the Look cleats.
Here is the Look pedal:
http://www.lookcycle.com/en/all/rout...keo-2-max.html




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