I've been taking a low dose for just over a year. I was very skeptical at first, as my doctor said I have subclinical hypothyroidism. It sounded like she just wanted to put me on something. I was therefore pleasantly surprised when I hit the six week mark and--bam!--I felt really, really great for the first time in years. I was also able to lose weight remarkable easily (I had to work at it, but my body responded more than it had before). So, I'm a believer now. I forget a lot of things, but I never miss my morning tablet.