So 2 days on either end wouldn't be unheard of.

I've got a large concern over the type of components that they use. The older style 10 speed Shimano parts causes a lot of wrist and hand pain for me, and did no matter what position I had them in. Supposedly the 6 series Madones use the new Dura Ace (better ergonomics,) but exactly how anal retentive are they with their fitting? And are they able to adjust things throughout the week if problems crop up?

Thanks for all the information everyone, it's very helpful.