I'm also osteoporotic and have had one Reclast injection, recommended by the endocrinologist. Like you, my stomach couldn't tolerate Fosamax. The injection itself was a breeze (given in the infusion therapy unit where the nurses are used to putting IV's in very sick chemotherapy patients, so are really good at it). You are warned to arrive for the infusion well hydrated and they want you to drink extra for 2 to 3 days post infusion. None of that was problematic. However, 6 months later, my routine blood work had a spike in my kidney values. My kidney values had never strayed from normal, even when I was in the midst of renal colic with a kidney stone. I gave my next injection (due back in June) a miss, and will make my final decision based on my next round of blood work in January and discussion with MD then.

Like you I have a very strong family history of osteoporosis, every woman on my father's side had at least a "Dowager's hump" and one of my aunt's had a vertebral fracture that left her permanently looking at the floor. My mother has had a sacral fracture that caused nerve damage, leaving her totally incontinent. That has severely impacted her quality of life. However, at this point, I'm inclined to take my chances. It's one thing for Simvastatin to give me slightly high liver values, the liver is good at regenerating. Kidneys are a different story. I'm not sure how much I'm willing to risk damaging my kidneys to reduce my fracture risk. After all, 2 out of 4 of my closest female reatives did not have any significant fractures. I really should have paid more attention in my statistics class.