something to consider about the saddle-- some cut-out "crotch saving" saddles have a "valley" between the padded bit that contacts the sit bones and nose. The selle italia atola is an example of this-- it has a diamond shape cutout, but also this valley that you can see if you look at the saddle from the side. Kind of a dip in the saddle, which I believe is supposed to help relieve pressure. Anyhow, I had some hand/arm discomfort with my newish custom bike (that otherwise fits fantastically well) and it was traced to my saddle. although the width was good for my sit bones, I tended to slide into the valley when riding (so, sliding a bit forward, off the padded bit) and compensated for this by holding myself in position farther back on the saddle with my arms. A new saddle that is more stable has eliminated this issue.

Anyhow, just another factor to consider, along with reach issues (stem, bars (reach to brakes, etc) as noted by others in the thread