Back in the 80's it seems to me, that every time I went in the bike store the chamois shorts had real chamois in them, meaning the kind of sheepskin that comes from real sheep. I haven't seen any of those recently, and I wonder if it would help? I don't even know if those are made anymore, or if it would be prohibitively expensive. It seems like a natural material would alleviate some female issues. Also, I try to not get any soap directly onto that area when I shower, just because it might get irritating. I did a century yesterday, and I used chamois buttr for the first time. I think I am probably less chafed than I might have been, but I still fell like someone dragged me through the sand! Not on any real important parts, but where my underwear seams are hitting it today.