from another post Meno woman.....my Gyno prescribed some estrogen cream, topically applied to address the thinning tissues which she says "everyone" has during and especially after Menopause. I often forget to use it but it does help and the tissues are much heartier now. I do find riding day after day without rest days does create soreness, though not rawness. I also use chamois butter and it helps a lot as well as very high quality shorts and changing positions often during a ride. PS. The estrogen cream does not get absorbed into the body but just the external tissues so should be perfectly safe for those of us who worry about taking estrogen.