Aly is absolutely right about regional differences within states...but it's not unique to the midwest.

Georgia has Atlanta...and then everything else
Tennessee has East (hill folk), Middle (cosmolitan), and West (agrarian)
Florida has very stark differences as well.

Historically, our part of Indiana was literally part of the Kentucky territory. As a result, people say "ya'll" (the proper way) and have very southern leanings. As a result, we're not really considered part of Indiana by the rest of the state...and we're closer to three other state capitals than our own!

I still vote for the Ohio River Valley Region...it's what the Weather Channel calls us.