I'll echo what everyone else has said. I prefer a cutout too. I don't know if my girly bits are especially large; I've never done a side-by-side comparison with anyone else!

Bike fit, seat angle, handlebar height, chamoise, etc. make a difference. I prefer the Sugoi RS shorts for whatever reason. The chamois works for me. Also keep in mind that saddles--like just about everything else on a bike--need to be replaced periodically. Saddles with cutouts break down even faster. I only got about a year out of my first Terry, which is consisent with what others have reported. Depending on how much and how hard you ride and the conditions you ride in, you may need to replace the saddle more or less often.