I have been using a combination of Chamois Butt'r, Queen Helene's Cocoa Butter Creme and Bag Balm for years. Still haven't found the "secret" to keep me completely comfortable during the entire ride. Today I decided to go without anything and see how I felt. It wasn't bad, still had some slight irritation but I think it was due to my saddle not being adjusted correctly. My husband had put my saddle slightly higher and forward a few days ago and returned the nose to level, which I didn't realize. If the nose had been tipped slightly down I think I would have had a more comfortable ride. Hopefully Sunday I can ride again (if it doesn't rain) and try my experiment all over again.