I suppose you don't know if it's the right fit, that's why there are trusty LBS's that know and will fit and fit and fit you until it's right. With all 3 bikes, I've bought them from the same store, and each time they do a complete fitting and then I come back for adjustments when needed (although the initial fitting is so comprehensive I've really not needed to go back to adjust much).
I think when it's comfortable from the get go, you don't need to do a lot of adjustments. It does take some time for the mind and body to get used to the idea tho- we can be stubborn, can't we?

So what bikes are you lusting after???